Women lead stressful lives. They do home management, do trouble shooting, manage kids, and cater to in-laws and relatives. This lifestyle hardly leaves room for them to think about themselves. A married life is equivalent to never ending series of duties. This leaves them with stressed out mind and body.
Studies show that if the woman is content in her marital life, her husband is happy with life in general. It definitely pays men with a happy life scenario when they keep their wives satisfied in marriage. Women need care and attentive listening apart from the financial and social security. So all you men should keep your spouse happy to make your own life happier!Alok adds : There will be some who can not be satisfied or made happy but above will work for most women.
Read the study in detail at Tasnimnews.com
Thursday, February 12, 2015
Wednesday, February 4, 2015
Vitaros may come to India which is a better alternative to Viagra
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8:01 PM (16 hours ago)
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Dear Alokji
Good news for the ED topical cream alternative which can become OTS and will fetch good revenue; useful for diabetic and heart patients without major side effects.
currently we chemist cannot dispense sildenafil formulations without prescription.
Regards
Anil
On Wed, Feb 4, 2015 at 6:49 PM, Alok Tholiya <atholiya@gmail.com> wrote:
Apricus Biosciences Expands Exclusive License Agreement With an Existing Partner to Market Vitaros(R) in Select Asia-Pacific CountriesApricus Eligible to Receive an Additional Upfront, Milestone Payment and a Double-Digit Royalty on Net SalesFebruary 03, 2015: 04:05 PM ETSAN DIEGO, Feb. 3, 2015 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. (Nasdaq:APRI), a biopharmaceutical company advancing innovative medicines in urology and rheumatology, today announced that it has further expanded its exclusive license agreement with Hexal AG, an affiliate within the Sandoz Division of the Novartis Group of Companies ("Sandoz"), for the commercialization of Vitaros®, Apricus' novel topical on-demand treatment for erectile dysfunction ("ED"). This amendment is in addition to the in-place collaboration established with Hexal AG in Germany in 2012, and the expansion of the cooperation in 2013 to include Austria, Belgium, Denmark, Finland, Iceland, Luxembourg, the Netherlands, Norway, Sweden and Switzerland. This expanded agreement includes Malaysia, Indonesia, the Philippines, Thailand, Taiwan, Vietnam, Hong Kong and Singapore (the "New Territory").In combination with the terms of the previously signed license agreements with Sandoz, Apricus is eligible to receive up to approximately $63.5 million in combined upfront, regulatory and sales milestone payments, which includes up to a total of $6.4 million in upfront and pre-commercialization payments, and a double-digit royalty rate for Vitaros."Leveraging our strong working relationships and expanding our existing Vitaros agreements with our collaboration partners is an on-going key initiative within Apricus," said Richard Pascoe, Chief Executive Officer of Apricus. "Having recently introduced Vitaros in Germany, Belgium and Sweden, Sandoz has set an impressive pace with their launch performance to date, and as such, we are very pleased that they have elected to increase their commitment to Vitaros in these important markets outside of Europe." Mr. Pascoe continued, "Moreover, we will continue to seek value creating partnerships in other available territories in an effort to bring this novel ED treatment to physicians and patients throughout the world."Vitaros is an exciting new entrant into the ED treatment market, offering a range of clear benefits that make it ideal for virtually any ED patient. Vitaros is a topical cream ED medication that delivers rapid onset (generally 5-15 minutes), a treatment duration of approximately 1 hour and an excellent safety profile. Vitaros' local delivery provides a very attractive alternative for all patients, but particularly those with complications that preclude them from using the orally delivered systemic treatments or who prefer to not use the injectable forms of alprostadil.According to the most recent estimates, the global ED market in 2013 was in excess of $5.5 billion annually. Vitaros has the potential to generate for Apricus over $215 million in future milestone payments, as well as additional potential royalty revenue on net product sales based upon double-digit royalty rates through its existing commercial partnerships. In addition, Apricus intends to leverage Vitaros through additional licensing efforts in key markets such a Japan and China in Asia and throughout Latin America.About Apricus Biosciences, Inc.Apricus Biosciences, Inc. (APRI) is a biopharmaceutical company advancing innovative medicines in urology and rheumatology. Apricus' lead product, Vitaros®, for the treatment of erectile dysfunction, is approved in Europe and Canada and is being commercialized in several countries in Europe. Apricus' marketing partners for Vitaros include Abbott Laboratories Limited, Takeda Pharmaceuticals International GmbH, Hexal AG (Sandoz), Recordati Ireland Ltd. (Recordati S.p.A.), Bracco S.p.A. and Laboratoires Majorelle. Apricus' second-generation Vitaros Room Temperature Device is under development and is expected to enhance the product's commercial value. The Vitaros trademark is registered or has pending applications for registration in certain countries and jurisdictions around the world. The mark is not registered in all of the countries mentioned above. Apricus recently commenced a Phase 2a trial for RayVa™, its product candidate for the treatment of the circulatory disorder Raynaud's phenomenon. Additionally, Apricus plans to initiate a Phase 2b trial for fispemifene, a selective estrogen receptor modulator for the treatment of male secondary hypogonadism, chronic prostatitis and lower urinary tract symptoms. Apricus is currently seeking a strategic partner to fund development of Femprox®, a product candidate for the treatment of female sexual interest/arousal disorder that completed an approximately 400-subject proof-of-concept study.For further information on Apricus, visit http://www.apricusbio.com. Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act, as amended. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things: references to the planned launches of Vitaros® in various countries by Sandoz; the potential for the product to achieve commercial success generally or in any specific territory; the size of the commercial opportunity for the product; and the timing of Phase 2 clinical trials for fispemifene. Actual results could differ from those projected in any forward-looking statements due to a variety of reasons that are outside the control of Apricus, including, but not limited to: its ability to further develop its product Vitaros for the treatment of erectile dysfunction, such as the room temperature version of Vitaros, and its product candidates RayVa for the treatment of Raynaud's phenomenon and fispemifene for the treatment of secondary hypogonadism, chronic prostatitis and lower urinary tract symptoms in men, as well as the timing of such events; Apricus' ability to carry out clinical studies for RayVa and fispemifene, as well as the timing and success of the results of such studies; potential adverse side effects or other safety risks associated with fispemifene and RayVa that could delay or preclude approval; Apricus' dependence on its commercial partners to increase sales of Vitaros in various territories, and the potential for delays in the timing of commercial launches in additional countries; competition in the erectile dysfunction market and other markets in which Apricus and its partners operate; Apricus' ability to obtain license partners for Vitaros; Apricus' ability to obtain and maintain intellectual property protection for Vitaros, RayVa, fispemifene or any other product candidates; Apricus' ability to raise additional funding that it may need to continue to pursue its commercial and business development plans; Apricus' ability to obtain the requisite governmental approval for Vitaros in the New Territory; and market conditions. These forward-looking statements are made as of the date of this press release, and Apricus assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements. Readers are urged to read the risk factors set forth in Apricus' most recent annual report on Form 10-K, subsequent quarterly reports filed on Form 10-Q, and other filings made with the SEC. Copies of these reports are available from the SEC's website at www.sec.gov or without charge from Apricus.CONTACT: Institutional Investors: Angeli Kolhatkar angeli@areciaadvisors.com Arecia Advisors (917) 387-44770 Retail Investors: Chris Eddy, David Collins apri@catalyst-ir.com Catalyst Global (212) 924-9800
Arginex or Arginin or Gyargin or L-Arginine benefits
Arginin Formel activated muscle build up and maximizes the pump during workout
Nitric Oxide's effects on athletic performance have been the foremost discovery in the sports nutrition sector since Creatine took the world by storm. This molecule, produced inside our bodies, gives the muscles a direct growth signal. And that is merely one of Nitric Oxide's advantages - 3 scientists involved in its discovery have already received the Nobel prize for medicine in 1998.
Arginex activates muscle growth around the clock
The name Nitric Oxide might sound like powerful rocket fuel. In reality, it is a molecule produced inside our body that possesses a veritable plethora of advantages for our health and performance. Scientists have been both baffled and excited by Nitric Oxide. Many at first refused to believe that a single molecule can be responsible for so many functions inside the body. It took Dr. Ferid Murad's, Dr. Robert F. Furchgott's and Dr. Louis Ignarro's winning the Nobel Prize for Medicine in 1998, based on their discovery of Nitric Oxide's signal effect in the body, for its functions to finally be validated and recognized.
What are the main benefits of Nitric Oxide ?
How can you provide your body with more Nitric Oxide?
Many studies show that the body's Nitric Oxide levels can be naturally and safely increased by the correct intake of the amino acid L-Arginine. Based on this research the powerful Nitric Oxide activator Arginex has been developed. Arginex contains the identical 100% free-form L-Arginine used in scientific studies to increase Nitric oxide production. To guarantee L-Arginine's maximum effectiveness, its formula also provides all critical co-factors for the activation of Nitric Oxide.
Arginex activates muscle growth
As has been proven, Nitric Oxide sends a growth signal to the muscle cells. This follows a simple rule: the higher the Nitric Oxide, the more powerful the muscle cells training-induced growth. Regular supplementation with Arginex will lift your Nitric Oxide level and allow you to gain more lean, hard muscle mass along with power, endurance and performance than has ever been thought possible.
Maximizes muscle pump during exercise
Arginex is also a powerful natural vasodilator. This means it expands blood vessels, thus promoting blood flow and enabling an extreme muscle pump during exercise. A high Nitric Oxide level lets you feel this pump not just during workouts but, to some extent, throughout the day. This is a sign that the muscles are continuously flushed with nutrients, allowing them to grow 24/7. This also reduces the muscles' recovery periods and permits maximum performance for the next workout or competition.
Increases growth hormone level
Growth hormone, often abbreviated as hGH, is the human body's foremost anti-aging hormone. It keeps us young, enhances fat-burning and promotes muscle growth. Arginex's L-Arginine is one of the amino acids which can stimulate the natural release of growth hormone. This lets you benefit from all of growth hormone's anti-aging effects without the need for injecting overpriced synthetic hGH.
Enhances potency
It is actually Nitric Oxide that signals the penis blood vessels to expand and fill with blood. The more Nitric Oxide, the stronger the erection. Arginex promotes potency in an all-natural fashion by delivering the building materials to release Nitric Oxide into the penis. Arginex does not immediately develop its full effectiveness but does so only after about a week of regular use. But it is free of side effects and allows you to benefit from all its other health- and performance-related functions. Arginex not only enhances potency, but also the quality of sperm. Studies have demonstrated that L-Arginine improves both sperm-count and -mobility.
Who should not use Arginex?
L-Arginine is known to promote the onset of cold sores (Herpes Simplex). Arginex therefore contains vital elements shown to suppress Herpes. If you are among those people who often suffer from Herpes Simplex, you should test your reaction to Arginex by using small dosages at first and then increasing them slowly. Should you still develop cold sores, you should discontinue Arginex usage. While the amino acid L-Lysine is known to avoid the onset of Herpes Simplex in many people, it is not contained in Arginex as it is a natural antagonist to L-Arginine and renders it ineffective. If you take L-Lysine, never do so at the same time as Arginex but choose a different time of day.
Benefits of Arginex:
Arginex's effectiveness is definitely dependent on its dosage. The more you take, the more Nitric Oxide is produced inside the body. The mentioned dosage should suffice to achieve optimal results. Should you find this not to be the case, the dosage can be increased up to twice that. Studies tested subjects onL-Arginine up to 30 grams. The only side effects were soft stools and iron erections.
How quickly can results be noticed?
After just 5 to 7 days you will feel a powerful pump while working out. Your muscles will feel fully engorged. This pump will not, as normally, disappear about 30 minutes after exercise but continue, to a certain extent, throughout the day. After an additional 2 to 3 days, you will feel increased power and endurance. You will experience a healthy tension in your muscles and notice an increase in solid muscle mass.
Combine Arginex with PowerCreatine for even better results
To maximize muscle growth, Arginex can be combined with PowerCreatine. These two products enhance each other and thus lead to an explosive gain in muscle mass and power. Arginex and PowerCreatine can even be taken at the same time.
Arginex activates muscle growth around the clock
The name Nitric Oxide might sound like powerful rocket fuel. In reality, it is a molecule produced inside our body that possesses a veritable plethora of advantages for our health and performance. Scientists have been both baffled and excited by Nitric Oxide. Many at first refused to believe that a single molecule can be responsible for so many functions inside the body. It took Dr. Ferid Murad's, Dr. Robert F. Furchgott's and Dr. Louis Ignarro's winning the Nobel Prize for Medicine in 1998, based on their discovery of Nitric Oxide's signal effect in the body, for its functions to finally be validated and recognized.
What are the main benefits of Nitric Oxide ?
- The list of Nitric Oxide's functions on the body is a long one. Among its foremost tasks in the areas of sports, muscle growth and health are:
- activates muscle growth
- maximizes muscle pump
- enhances energy, power and performance
- accelerates regeneration
- normalizes blood pressure
- protects heart and cariovascular system
- relaxes blood vessels
- optimizes sensitivity to Insulin
- enhances erectile function
How can you provide your body with more Nitric Oxide?
Many studies show that the body's Nitric Oxide levels can be naturally and safely increased by the correct intake of the amino acid L-Arginine. Based on this research the powerful Nitric Oxide activator Arginex has been developed. Arginex contains the identical 100% free-form L-Arginine used in scientific studies to increase Nitric oxide production. To guarantee L-Arginine's maximum effectiveness, its formula also provides all critical co-factors for the activation of Nitric Oxide.
Arginex activates muscle growth
As has been proven, Nitric Oxide sends a growth signal to the muscle cells. This follows a simple rule: the higher the Nitric Oxide, the more powerful the muscle cells training-induced growth. Regular supplementation with Arginex will lift your Nitric Oxide level and allow you to gain more lean, hard muscle mass along with power, endurance and performance than has ever been thought possible.
Maximizes muscle pump during exercise
Arginex is also a powerful natural vasodilator. This means it expands blood vessels, thus promoting blood flow and enabling an extreme muscle pump during exercise. A high Nitric Oxide level lets you feel this pump not just during workouts but, to some extent, throughout the day. This is a sign that the muscles are continuously flushed with nutrients, allowing them to grow 24/7. This also reduces the muscles' recovery periods and permits maximum performance for the next workout or competition.
Increases growth hormone level
Growth hormone, often abbreviated as hGH, is the human body's foremost anti-aging hormone. It keeps us young, enhances fat-burning and promotes muscle growth. Arginex's L-Arginine is one of the amino acids which can stimulate the natural release of growth hormone. This lets you benefit from all of growth hormone's anti-aging effects without the need for injecting overpriced synthetic hGH.
Enhances potency
It is actually Nitric Oxide that signals the penis blood vessels to expand and fill with blood. The more Nitric Oxide, the stronger the erection. Arginex promotes potency in an all-natural fashion by delivering the building materials to release Nitric Oxide into the penis. Arginex does not immediately develop its full effectiveness but does so only after about a week of regular use. But it is free of side effects and allows you to benefit from all its other health- and performance-related functions. Arginex not only enhances potency, but also the quality of sperm. Studies have demonstrated that L-Arginine improves both sperm-count and -mobility.
Who should not use Arginex?
L-Arginine is known to promote the onset of cold sores (Herpes Simplex). Arginex therefore contains vital elements shown to suppress Herpes. If you are among those people who often suffer from Herpes Simplex, you should test your reaction to Arginex by using small dosages at first and then increasing them slowly. Should you still develop cold sores, you should discontinue Arginex usage. While the amino acid L-Lysine is known to avoid the onset of Herpes Simplex in many people, it is not contained in Arginex as it is a natural antagonist to L-Arginine and renders it ineffective. If you take L-Lysine, never do so at the same time as Arginex but choose a different time of day.
Benefits of Arginex:
- more lean muscle mass
- activates fat-burning
- more power and elasticity
- more endurance and performance
- faster regeneration
- extreme muscle pump
- enhances virility
Arginex's effectiveness is definitely dependent on its dosage. The more you take, the more Nitric Oxide is produced inside the body. The mentioned dosage should suffice to achieve optimal results. Should you find this not to be the case, the dosage can be increased up to twice that. Studies tested subjects onL-Arginine up to 30 grams. The only side effects were soft stools and iron erections.
How quickly can results be noticed?
After just 5 to 7 days you will feel a powerful pump while working out. Your muscles will feel fully engorged. This pump will not, as normally, disappear about 30 minutes after exercise but continue, to a certain extent, throughout the day. After an additional 2 to 3 days, you will feel increased power and endurance. You will experience a healthy tension in your muscles and notice an increase in solid muscle mass.
Combine Arginex with PowerCreatine for even better results
To maximize muscle growth, Arginex can be combined with PowerCreatine. These two products enhance each other and thus lead to an explosive gain in muscle mass and power. Arginex and PowerCreatine can even be taken at the same time.
Tuesday, January 27, 2015
Protect Your Erection: 11 Tips....By David Freeman
The last but not least is Stress: To protect erections one must not do anything in vocation which can give stress. Also wife, children and bosses must not give stress. .....Alok
Protect Your Erection: 11 Tips
How to avoid erectile dysfunction and protect your potency.
Reviewed by David T. Derrer, MD
Erectile dysfunction (ED) becomes more common as men age. But it is not necessarily a normal part of aging. How can you avoid ED? Here's what experts told WebMD.
1. Watch what you eat.
A diet that's bad for a man's heart is also not good for his ability to have erections.
Research has shown that the same eating patterns that can cause heart attacks due to restricted blood flow in the coronary arteries can also impede blood flow to and within the penis. The blood flow is needed for the penis to become erect. Diets that include very few fruits and vegetables along with lots of fatty, fried, and processed foods can contribute to decreased blood circulation throughout the body.
Anything that is bad for a man's heart is also bad for his penis, says Andrew McCullough, MD, associate professor of clinical urology and director of the male sexual health program at New York University Langone Medical Center.
Recent studies show that ED is relatively uncommon among men who eat a traditional Mediterranean diet, which includes fruits, vegetables, whole grains, heart-healthy fats including nuts and olive oil, fish.
"The link between the Mediterranean diet and improved sexual function has been scientifically established," says Irwin Goldstein, MD, director of sexual medicine at Alvarado Hospital in San Diego.
2. Maintain a healthy weight.
Being overweight can bring many health problems, including type 2 diabetes, which can cause nerve damage throughout the body. If the diabetes affects the nerves that supply the penis, ED can result.
3. Avoid high blood pressure and high cholesterol.
High cholesterol or high blood pressure can damage blood vessels, including those that bring blood to the penis. Eventually, this may lead to ED.
Make sure your doctor checks your cholesterol levels and blood pressure. You might also want to check your blood pressure between doctor visits. Some stores and fire stations offer free screenings. Blood pressure monitors are also sold for home use.
If your cholesterol or blood pressure is out of whack, get it treated.
Blood pressure drugs can make it hard to get an erection. But doctors say many cases of ED that get blamed on these drugs are actually caused by arterial damage resulting from high blood pressure (also called hypertension).
4. Drink alcohol in moderation or not at all.
There is no evidence that mild or even moderate alcohol consumption is bad for erectile function, says Ira Sharlip, MD, a urology professor at the University of California San Francisco School of Medicine. But chronic heavy drinking can cause liver damage, nerve damage, and other conditions -- such as interfering with the normal balance of male sex hormone levels -- that can lead to ED.
5. Exercise regularly.
Strong evidence links a sedentary lifestyle to erectile dysfunction.Running, swimming, and other forms of aerobic exercise have been shown to help prevent ED.
Watch out for any form of exercise that puts excessive pressure on the perineum, which is the area between the scrotum and anus. Both the blood vessels and the nerves that supply the penis can be adversely affected from excessive pressure in this area. Goldstein says bicycle riding, in particular, can cause ED.
An occasional short ride is unlikely to cause trouble. But men who spend a lot of time biking should make sure their bike fits them properly, wear padded cycling pants, and stand up frequently while pedaling.
"No-nose" bike seats protect against genital numbness and sexual dysfunction, according to the National Institute for Occupational Safety and Health.
6. Don't rely on Kegels.
One form of exercise that doesn't seem helpful is Kegel exercises, which involve repeatedly contracting and relaxing the muscles in the pelvis. Kegels can be helpful for men and women suffering from incontinence. But there's no evidence that they prevent erectile dysfunction.
7. Keep tabs on testosterone.
Even in healthy men, testosterone levels often begin falling sharply around age 50. Every year after age 40, a man's testosterone level typically falls about 1.3%.
Symptoms like a low sex drive, moodiness, lack of stamina, or trouble making decisions suggest a testosterone deficiency, as do lackluster erections. Your doctor can check on that.
8. Avoid anabolic steroids.
These drugs, which are often abused by athletes and bodybuilders, can shrink the testicles and sap their ability to make testosterone.
9. If you smoke, stop.
Smoking cigarettes can harm blood vessels and curb blood flow to the penis. And nicotine makes blood vessels contract, which can hamper blood flow to the penis.
10. Steer clear of risky sex.
Believe it or not, some cases of erectile dysfunction stem from penile injuries that occur during sex. Taking your time and avoiding certain positions can help. It may be uncomfortable, but consider talking to your doctor about what to do and, more importantly, what not to do.
11. Curb stress.
Psychological stress boosts levels of the hormone adrenaline, which makes blood vessels contract. That can be bad news for an erection. Anything a man can do to ease tension and feel better emotionally is likely to give his sex life a big boost.
Friday, November 21, 2014
Hyperprolactinemia and Erectile Dysfunction
Hyperprolactinemia and Erectile Dysfunction
Hyperprolactinemia can also cause visual field defect............Alok
Wednesday, November 12, 2014
Sunday, October 26, 2014
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